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GLUCOSAMINE & CHONDROITIN &
MSM
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Chondroitin, glucosamine and MSM,
as dietary supplements, are used
together to help ease the
symptoms of osteoarthritis.
Glucosamine is a form of amino
sugar that is believed to play a
role in cartilage formation and
repair. Chondroitin sulfate is
part of a large protein molecule
(proteoglycan) that gives
cartilage elasticity. MSM is a
source of biological sulfur,
which is a major component in
many of the body's proteins,
tissues, hormones and enzymes. |
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Glucosamine &
Chondroitin & MSM
available in:
90 count Tablets View
Supplement/Nutrition Facts |
Glucosamine, chondroitin sulfate and MSM are
substances found naturally in the body.
Glucosamine is a form of amino sugar that is
believed to play a role in cartilage
formation and repair. Chondroitin sulfate is
part of a large protein molecule (proteoglycan)
that gives cartilage elasticity. MSM is a
source of biological sulfur, which is a
major component in many of the body’s
proteins, tissues, hormones and enzymes.
Increased activity/exercise, damages to the
body and degenerative diseases may overcome
the rate at which they are produced and used
affecting the production of proteoglycans.
This in turn decreases synovial fluid that
cushions and prevents the joints from
rubbing together. Cartilage can begin to
deteriorate and weaken (less collagen)
producing damage, stiffness and pain.
Osteoarthritis is associated with a
breakdown of cartilage in joints and
commonly occurs in the hips, knees and
spine. Osteoarthritis occurs when there is
significant wearing of the articular
cartilage of the joint. Articular cartilage
is the cushioning substance on the ends of
bones and consists of glycosaminoglycans.
This substance is very viscoelastic and
works well as a cushion. As the articular
cartilage is worn down, swelling and pain
occur due to inflammation.
Chondroitin, glucosamine and MSM, as
dietary supplements, are used together to
help ease the symptoms of osteoarthritis.
Glucosamine is an amino sugar normally
produced in the human body. It is necessary
for the construction and repair of
connective tissue and healthy joint
cartilage. Cartilage is the protein part of
the fibrous substance that holds the joints.
It is also used in the formation of tendons,
membranes, bones and other tissues.
Glucosamine is a major building block of
proteoglycans and is needed to make
glycosaminoglycans: proteins that bind water
in the cartilage matrix. Regular intake of
glucosamine has been shown to slow
Osteoarthritis progression by halting joint
space narrowing and so maintain the health
and mobility of the affected joints.
Chondroitin sulfate also occurs naturally
in the body. Like glucosamine, chondroitin
is a building block of proteoglycans: large
protein molecules that give cartilage
elasticity. Chondroitin sulfate acts by
attracting fluid into the proteoglycan
molecules and stimulates collagen
production, an ingredient that forms part of
the cushioning structure at the ends of the
joints. Oral administration of chondroitin
also prompts a significant increase in
hyaluronic acid, a major component of
synovial fluid: the lubricating fluid in
joints.
Methyl Sulfonyl Methane (MSM) is a
nutritional form of sulfur. MSM acts as a
transport molecule for elemental sulfur,
which is required for the amino acids:
methionine and cysteine. Amino acids are the
building blocks of protein. Proteins are
required for growth and repair and are
involved in; the formation of healthy
connective tissues, joint function, proper
enzyme activity and hormone balance, along
with the proper function of the immune
system. MSM has very important roles in the
body because of its close relationship with
proteins.
MSM is useful for relieving inflammation
and pain in joints that are associated with
osteoarthritis, rheumatoid arthritis, muscle
pain, fatigue and back pain. MSM relieves
inflammation and pain by helping to equalize
cell pressure. |
SELECTED REFERENCES
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Chou MM, Vergnolle N, McDougall JJ, Wallace JL,
Marty S, Teskey V, Buret AG.
Effects of chondroitin and glucosamine sulfate in a dietary bar
formulation on
inflammation, interleukin-1beta, matrix metalloprotease-9, and
cartilage damage in
arthritis. Exp Biol Med (Maywood). 2005 Apr;230(4):255-62.
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Hathcock JN, Shao A. Risk assessment for
glucosamine and chondroitin sulfate. Regul
Toxicol Pharmacol. 2007 Feb;47(1):78-83. Epub 2006 Aug 30.
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Kim LS, Axelrod LJ, Howard P et al. Efficacy of
methylsulfonylmethane (MSM) in
osteoarthritis pain of the knee: a pilot clinical trial.
Osteoarthritis Cartilage. 2006
Mar;14(3):286-94. Epub 2005 Nov 23.
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Reginster JY, Deroisy R, Rovati LC, Lee RL,
Lejeune E, Bruyere O, Giacovelli G,
Henrotin Y, Dacre JE, Gossett C. Long-term effects of glucosamine
sulphate on
osteoarthritis progression: a randomised, placebo-controlled
clinical trial. Lancet. 2001
Jan 27;357(9252):251-6.
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Usha P.R., Naidu M.U.R. Randomised, double-blind,
parallel, placebo-controlled study
of oral glucosamine, methylsulfonylmethane and their combination in
osteoarthritis.
Clinical Drug Investigation. 24(6):353-363, 2004.
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FREQUENTLY
ASKED QUESTIONS
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Who should take Glucosamine & Chondroitin &
MSM?
It is recommended for anyone with uncomfortable, stiff and aching
joints. It can also benefit those who participate in regular
physical activity by helping to maintain joint health and reduce
stress from repetitive or jarring motions.
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Is there anyone who shouldn’t take this
product?
If you are allergic to shellfish or fish, consult your doctor before
deciding to take Glucosamine & Chondroitin & MSM.
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How long will it take for me to feel positive
results?
The benefits of Glucosamine & Chondroitin & MSM supplementation
develop over time. Generally, it may take 2 to 8 weeks before you
see noticeable results.
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What is MSM and why is it recommended?
MSM is a natural sulfur-containing compound that is produced in the
human body. Although MSM occurs naturally in foods, even moderate
food processing destroys most of it. It provides an important source
of sulfur, which plants, animals and humans need for a wide variety
of processes.
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