ISOPREME
WHEY ISOLATE

Glutathione is a tripeptide made up of the amino acids, cysteine, glutatmine and glycine. Whey protein has the largest concentration of glutathione boosting amino acids compared to any other protein. Glutathione is a natural antioxidant found in the human body and provides the fundamental cellular defense against oxidative stress caused by free radicals. The consumption of proteins containing cysteine, glutamine and glycine helps maintain strong glutathione levels.

Glutathione is important to maintaining the immune system. Immune lymphocytes depend on glutathione for normal replication and function. Research published in the journal Immunology shows the depletion of glutathione has harmful effects upon natural killer cell function and the strength of lymphocytes. Additionally, glutathione has been found to be depleted in individuals with chronic disease.

Glutathione also detoxifies many pollutants in the body. It is found in very high concentrations in the liver, the main detoxification organ in the body. Studies have shown that individuals with poor liver function, due to disease or alcohol abuse, have depleted levels of glutathione. Supplementing with whey protein helps boost glutathione to enhance liver health and detoxification processes.

One of the greatest benefits of whey protein is that it improves immune function and, notably, elevates cellular glutathione levels. Glutathione is one of body's own potent antioxidants. Furthermore, glutathione is a detoxifying agent that neutralizes the free radical metabolites, toxic metals such as aluminum, chemical carcinogens, and prevents lipid peroxidation of the cell membrane, which if left unchecked could break the cells open.

Ultimate Nutrition's Isopreme Bioactive Whey Isolate is produced exclusively through a new and innovative technology, ColdPure ultrafiltration. ColdPure ultrafiltration isolates the native whey protein in a highly bioactive form using an advanced low temperature ultrafiltration process. ColdPure ultrafiltration produces a superior Bioactive whey that is non-denatured and contains the highest content of essential amino acids (EAA’s) and branched chain amino acids (BCAA’s).

Isopreme Bioactive Whey Isolate contains all the bioactive whey protein fractions such as Beta Lactoglobulin (55%), Alpha Lactalbumin (23%), Glycomacropeptide (12%), Immunoglobulin (5%), Serum Albumin (3%), Proteose Peptone (2%), and naturally occurring lactoferrin and lactoperoxidase. Isopreme Bioactive Whey Isolate contains over 50% EAA’s and 26% BCAA’s.

1. Bounous G, Gervais F, Amer V, Batist G, Gold P. The influence of dietary whey protein
   on tissue glutathione and the diseases of aging. Clin Invest Med (1989 Dec) 12(6):343-9.
2. Kennedy RS Konok GP Bounous G Baruchel S Lee TD. Whey and Cancer. Anticancer
   Res (1995 Nov-Dec) 15(6B):2643-9.
3. Kent KD, Harper WJ, Bomser JA.. Effect of whey protein isolate on intracellular
   glutathione and oxidant-induced cell death in human prostate epithelial cells.. Toxicol In
   Vitro. (2003 Feb) 17(1):27-33.
4. Liang SM, Liang CM, Hargrove ME, Ting CC. Regulation by glutathione of the effect of
   lymphokines on differentiation of primary activated lymphocytes. Influence of
   glutathione on cytotoxic activity of CD3-AK-. J. Immunol., (1991 Mar) 146: 1909 -
   1913.
5. Micke P, Beeh KM, Buhl R.. Effects of long-term supplementation with whey proteins
   on plasma glutathione levels of HIV-infected patients.. Eur J Nutr. (2002 Feb) 41(1):12-
   8.
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   to dietary whey protein supplementation in sedentary and trained male human subjects.
   Int J Food Sci Nutr. (2004 Mar) 55(2):131-41.

1. Who benefits from protein?
   Protein is an important nutrient needed by everyone of a daily basis. It is made up of
   essential and non-essential amino acids, which are the "building blocks" for healthy
   bodies. Protein has a number of different roles in the body including repairing body cells,
   building and repairing muscles and bones, providing a source of energy, and controling
   many of the important processes in the body related to metabolism. Whey protein is a
   high quality, complete protein, with all the essential amino acids. Whey protein is also
   the richest known source of naturally occurring branched chain amino acids (leucine,
   isoleucine and valine). These are important for active individuals, individuals who
   exercise and professional athletes. The body requires higher amounts of branched chain
   amino acids during and following exercise as they are taken up directly by the skeletal
   muscles versus first being metabolized through the liver, like other amino acids. Low
   BCAA levels contribute to fatigue and they should be replaced in one-hour or less
   following exercise or participation in a competitive event. Many athletes consume a whey
   beverage both before and immediately after exercise or an event to help repair and
   rebuild lean muscle tissue.
    

2. What is a glycomacropeptide?
   Glycomacropeptide (GMP) is a casein-derived whey peptide. Beneficial biological roles
   attributed to GMP or peptides derived from it include stimulation of cholecystokinin (a
   hormone regulating energy and food intake) release from intestinal cells, inhibition of
   platelet aggregation and support of beneficial intestinal bacteria (i.e., Bifidobacteria).
   Studies have also shown that GMP may help to reduce dental caries. GMP-rich whey
   protein concentrate is also a good source of branched-chain amino acids, which have
   been shown to promote lean muscle development. Ongoing research on the role of GMP
   as an appetite suppressant is very positive.
    

3. Why are branched-chain amino acids (BCAAs) important to athletes?
   BCAAs are unique because they can provide an energy source to muscles during
   endurance exercise. They are metabolized directly by skeletal muscles during prolonged
   exercise, while other amino acids are metabolized in the liver. Numerous studies have
   demonstrated that BCAAs improve protein synthesis and reverse overnight muscle tissue
   catabolism. Whey proteins contain the highest concentration of the branched-chain amino
   acids—leucine, isoleucine and valine available from any protein source.